After securing their maiden T20I victory over India in the series opener, the Irish backed it up with an even more dramatic performance, defending 154 to seal their first-ever bilateral series win against India.
Asked to bat first, Ireland recovered from an early wobble through Harry Tector, who anchored the innings with a composed 53 off 47 balls.
Ben Calitz provided the late impetus with a quickfire 37 from 23 deliveries, while George Dockrell chipped in with 19 as the hosts posted 154 for 8.
For India, Prince Yadav impressed with 3 for 22, while Shivam Dube and Arshdeep Singh claimed two wickets apiece.
India's chase got off to a disastrous start as Jai Moondra removed Sanju Samson and Abhishek Sharma in the opening over before dismissing captain Shreyas Iyer, leaving the visitors reeling at 19 for 3.
Tilak Varma fought back with a determined 55 off 46 balls and shared useful partnerships with Axar Patel (14) and Shivam Dube (20) to keep India's hopes alive.
However, regular breakthroughs from Matt Hollard, who claimed 3 for 26, and Matthew Humphreys prevented the visitors from gaining control.
Needing eight runs from the final over, India remained in contention until Harry Tector dismissed Harshit Rana off the penultimate ball.
Arshdeep Singh managed only a single before Prince Yadav smashed a six off the final delivery, but it wasn't enough as India finished on 153 for 9, agonisingly one run short.
Moondra and Hollard starred with three wickets each for Ireland, while Humphreys and Harry Tector chipped in with one apiece.
The back-to-back victories completed a landmark 2-0 series triumph for Ireland, marking their first bilateral T20I series win over India and one of the biggest achievements in Irish cricket history.