The initial group features a mix of youth and experience, including Shaheen Shah Afridi and Salman Ali Agha.
However, star batter Babar Azam was not part of the first contingent.
Several senior players, including Babar, are currently engaged in the Pakistan Super League final and are expected to join the squad in Bangladesh later after completing their commitments.
The 16-member squad announced by the Pakistan Cricket Board includes four uncapped players, marking a significant selection shift.
Under the leadership of Shan Masood, Abdullah Fazal, Amad Butt, Azan Awais and Muhammad Ghazi Ghori have all received their maiden call-ups.
The two-match series will be played in Mirpur and Sylhet. The first Test is scheduled to begin on May 8 at the Sher-e-Bangla National Cricket Stadium, while the second Test will be held at the Sylhet International Cricket Stadium from May 16.
