The 21-year-old will step in for regular white-ball skipper Harry Brook, with the series taking place in Dublin from Wednesday, September 17.
Hampshire fast bowler Sonny Baker, 22, who has caught attention with his performances for Manchester Originals in The Hundred, has received his maiden senior England call-up for the tour.
England have also confirmed their squads for the upcoming ODI and T20I series against South Africa, scheduled before the Ireland series.
England T20 squad for Ireland: Jacob Bethell (capt), Rehan Ahmed, Sonny Baker, Tom Banton, Jos Buttler (wk), Liam Dawson, Tom Hartley, Will Jacks, Saqib Mahmood, Jamie Overton, Matthew Potts, Adil Rashid, Phil Salt (wk), Luke Wood.
England ODI squad for South Africa: Harry Brook (capt), Rehan Ahmed, Jofra Archer, Sonny Baker, Tom Banton, Jacob Bethell, Jos Buttler (wk), Brydon Carse, Ben Duckett, Will Jacks, Saqib Mahmood, Jamie Overton, Adil Rashid, Joe Root, Jamie Smith (wk).
England T20 squad for South Africa: Harry Brook (capt), Rehan Ahmed, Jofra Archer, Tom Banton, Jacob Bethell, Jos Buttler (wk), Brydon Carse, Liam Dawson, Ben Duckett, Will Jacks, Saqib Mahmood, Jamie Overton, Adil Rashid, Phil Salt, Jamie Smith (wk), Luke Wood.
